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DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes
(2009-09-15)
Background: Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein (DNA-HSP65) displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protection ...
Influência da idade e da doença colorretal na imunocompetência cutânea peri-colostômica
(Cidade Editora Científica Ltda, 2009-12-01)
Objective: describe the immunological response in the dermal layer of the peri-colostomic region. Method: Forty-one patients with colostomies realized over eight weeks previously, were included. For the analysis of the ...
Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anaesthesia
(Oxford University Press, 2011-05-01)
There are numerous studies reporting on the effects of inhalation anaesthesia in cells of exposed individuals but not much is known about the ability of isoflurane (ISF) to induce oxidative DNA damage. However, surgery is ...
Papel das proteínas Yops de Yersinia pseudotuberculosis na ativação dos linfócitos B
(2003-12-01)
The virulence plasmid common to pathogenic Yersinia species encodes a number of secreted proteins denoted Yops (Yersinia outer proteins). The Yops effectors have been related to a set of biological properties, including ...
Evaluation of Cyto- and Genotoxicity of Poly(lactide-co-glycolide) Nanoparticles
(Springer/plenum Publishers, 2011-03-01)
This work reports on an analysis of the cyto- and genotoxicity of poly(lactide-co-glycolide) polymer nanoparticles, in an attempt to evaluate their mutagenic effects. Fibroblast (3T3) and human lymphocyte cell cultures ...
Antitumor properties of Ganoderma lucidum polysaccharides and terpenoids
(2011-12-01)
Ganoderma lucidum is an edible medicinal mushroom with immunomodulatory and antitumor properties, which are mainly attributed to polysaccharides and triterpenes that can be isolated from mycelia, fruiting bodies and spores. ...
Morphofunctional evaluation of thymus in hyperglycemic-hypoinsulinemic mice during dermatophytic infection
(Wiley-Blackwell, 2011-06-01)
Many works have shown that the enhanced susceptibility to infection seen in diabetic patients can be related to the hyperglycemia-hypoinsulinemia (HH) observed in this condition. Herein, we evaluated the HH effects on the ...
Enhanced natural killer activity and production of pro-inflammatory cytokines in mice selected for high acute inflammatory response (AIRmax)
(Blackwell Publishing, 2007-03-01)
Strains of mice with maximal and minimal acute inflammatory responsiveness (AIRmax and AIRmin, respectively) were developed through selective breeding based on their high- or low-acute inflammatory responsiveness. Previous ...
Lower levels of oxidative DNA damage and apoptosis in lymphocytes from patients undergoing surgery with propofol anesthesia
(Wiley-Blackwell, 2012-01-01)
Propofol, which is widely used as an intravenous anesthetic, has a phenolic structure similar to that of a-tocopherol with antioxidant properties that could prevent genotoxicity and cytotoxicity in lymphocytes of anesthetized ...